Ginsenoside Rg12, a new dammarane-type triterpene saponin from Panax ginseng root
نویسندگان
چکیده
BACKGROUND Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects. METHODS A dammarane-type triterpene saponin was isolated from P. ginseng root through chromatography such as repeated column chromatography and medium pressure liquid chromatography. RESULTS AND CONCLUSION New dammarane-type triterpene saponin was isolated for the first time from nature. The structure was elucidated as ginsenoside Rg12 (1) based on spectral data. There may be good materials from P. ginseng for the development of industrial applications such as nutraceutical, pharmaceutical, and cosmeceutical purposes.
منابع مشابه
Studies on dammarane-type saponins in the flower-buds of Panax ginseng C.A. Meyer.
From the dried flower-buds of Panax ginseng C.A. Meyer, a new minor dammarane-type triterpene saponin named ginsenoside III together with nine known saponins was isolated. On the basis of spectral and chemical evidence, the structure of the new saponin was elucidated as 3-O-[beta-D-glucopyranosyl(1-->2)-beta-D-glucopyranosyl]-20-O-beta- D-glucopyranosyl-3 beta,12 beta,20(S)-trihydroxy-dammar-25...
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Ginseng, the famous plant drug, has been used as an expensive traditional medicine in oriental countries. The main ginseng plants of this drug are Panax ginseng C. A. MEYER, P. quinquefolium L. (American ginseng), P. natoginseng (Sanchi ginseng, or Tienchi ginseng), P. japonicus, and other species of Panax genus. One of physiological activity materials of ginseng plants is saponin (ginsenoside)...
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